RESEARCH ON DATA INTEGRATION PRIVACY PRESERVATION MECHANISM FOR DAAS




Discovering covalent cyclic peptide inhibitors of peptidyl arginine deiminase 4 (PADI4) using mRNA-display with a genetically encoded electrophilic warhead

Abstract Covalent drugs can achieve high potency with long dosing intervals.However, concerns remain about side-effects associated with off-target reactivity.Combining Bench macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly reac

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The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.

Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore domain K(+) channel associated with muscle membranes.We cloned sup-18 and found that it encodes the C.elegans ortholog of mammalian

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